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HCG

Also known as: Human Chorionic Gonadotropin, Pregnyl, Novarel, Ovidrel

Hormonal FDA Approved

Human chorionic gonadotropin (luteinizing-hormone analog)

Mechanism of Action

Mimics luteinizing hormone (LH), stimulating gonadal sex-hormone production. Used clinically for fertility/hypogonadism, and in the community for testosterone/fertility support and post-cycle protocols.

Note: Fertility and hypogonadism indications

390
Community Posts
137
Users Discussing
12
Research Articles
4
Clinical Trials

Reported Outcomes

Clinical grade reflects published research; Community grade reflects user reports (n=390).

Sleep Quality

Effects on sleep quality

Clinical: D
Community: B
21% (45)
Mental/Mood

Effects on mood and cognitive function

Clinical: D
Community: B
10% (15)
Energy Levels

Changes in energy and fatigue levels

Clinical: D
Community: A
8% (14)

Who Discusses HCG

From community reports with demographic data.

Gender (limited data)

Male 100%

n=15

Side Effects

Limited data

Based on 16 user reports (n=16). Frequency indicates how often each was mentioned.

Common (>5%)

Fatigue
Mild 2 reports 10.5%
Insomnia
Mild 2 reports 10.5%
Acid Reflux
Mild 2 reports 10.5%
Heartburn
Mild 2 reports 10.5%

Uncommon (1-5%)

Hcg Protocol Difficulty
Mild 1 reports 5.3%
Wasted Feeling During And After Workout
Mild 1 reports 5.3%
Lightheadedness
Mild 1 reports 5.3%
Feeling Hypo During Workouts
Mild 1 reports 5.3%
Chills
Mild 1 reports 5.3%
Constantly Freezing
Mild 1 reports 5.3%
Frequent Urination (Polyuria)
Mild 1 reports 5.3%

Risks & Warnings

Important safety considerations based on clinical data and community reports.

i

Injection Site Reactions

7 mentions

Local reactions are common and usually mild. Rotate injection sites.

Dosing

Standard Protocol

Starting Dose
Indication-specific (e.g. 250-500 IU 2-3x weekly for TRT-adjacent fertility support)
Titration
No general protocol; indication-specific
Half-life
~24-36 hours
Administration
Subcutaneous or intramuscular injection

Community Dosing Patterns

Based on 21 mentions

Community-reported patterns, not medical advice.

5000IU
1
500 iu 3x/week
1
500 iu 2x/week
1
350 iu 3x/week
1
500mcg 3x/week
1

Research

12
Total Articles
4
Clinical Trials
4
Reviews

Key Studies

Research Progress on the Impact of Human Chorionic Gonadotropin on Reproductive Performance in Sows. Review

Animals (Basel) (2024)

Extragonadal actions of chorionic gonadotropin. Review

Rev Endocr Metab Disord (2011)

hCG, the wonder of today's science. Review

Reprod Biol Endocrinol (2012)

Human Chorionic Gonadotropin as a Pivotal Endocrine Immune Regulator Initiating and Preserving Fetal Tolerance. Review

Int J Mol Sci (2017)

Human Chorionic Gonadotrophin (hCG) induces changes in IFN-pathway and Interferon-Stimulated Genes (ISGs) on the bovine endometrium at Day 18 of pregnancy. Preclinical

Anim Reprod (2024)

Commonly Stacked With

From community members' documented stacks involving HCG.

Retatrutide 12 stacks (28.6%)
GHK-Cu 4 stacks (9.5%)
NAD+ 4 stacks (9.5%)
TB-500 4 stacks (9.5%)
BPC-157 4 stacks (9.5%)

Switching Patterns

Based on 18 discussions about switching to or from HCG.