Cagrilintide + Tirzepatide

Cagrilintide + Tirzepatide (Cagrilintide + Tirzepatide) appears in 137 author journeys (81 as actual concurrent use). Common goals: Weight loss and appetite suppression; appetite suppression; weight loss, appetite suppression. Typical doses reported: Cagrilintide 0.5mg, Tirzepatide 15mg. Reported side effects include: Fatigue/tiredness (especially at 0.5mg and up), nausea at the 1mg dose Research: 6 studies discuss two or more of these components together (6 clinical); the components appear across 488 studies in total.

Research support

6 research studies discuss two or more of these components together (6 clinical). Per-component literature:

PubMed/PMC articles mentioning each compound in title or abstract.

Typical doses reported

Community-reported doses are not medical guidance.

How people are running it

What people use it for

Sample reported outcomes

• ✓ At 1mg of cagrilintide, there were diminishing returns on appetite suppression. While there was strong suppression initially (to the point of nausea), it wore off quickly. Author concluded the juice wasn't worth the squeeze.
• ✓ Barely-functioning exhaustion and lowered mood
• ✓ Successfully reached and maintained goal weight (lost 75 lbs, going from 226 lbs to 169 lbs). The addition of Cagrilintide successfully extended the satiety/appetite suppression window of Tirzepatide and unstuck weight loss.
• ✓ Increasing protein intake made a world of difference in managing burnout.
• ✓ It is helping, but not providing the desired level of energy boost ('punch').
• ✓ Successfully maintaining weight at 53 kg (down from 88 kg) and experiencing increased appetite suppression, which allows the author to stay on a lower dose of Tirzepatide.
• ✓ Weight loss stopped immediately after discontinuing the Cagrilintide portion of the stack.
• ✓ Weeks 1-2: nothing of note. Week 3: felt similar to Tirzepatide working, helped for about 5 days. Week 4: burping sensation for 15 minutes. Week 5: no noticeable effect.

Self-reported community experiences, not verified results.

Sample reported side effects

• ⚠ Fatigue/tiredness (especially at 0.5mg and up), nausea at the 1mg dose
• ⚠ Extreme fatigue/exhaustion, decreased mood
• ⚠ Discarded an initial transit-delayed Cagrilintide vial due to a suspected lack of efficacy from temperature exposure. No injection sting noted with filtered Amo C5 Cagrilintide.
• ⚠ Very burnt out (fatigue)
• ⚠ Burnt out
• ⚠ Fatigue
• ⚠ Very mild stomach discomfort (Week 1), brief burping sensation (Week 4)
• ⚠ Overwhelming fatigue and lack of energy on day 2 after taking 0.25mg of Cagrilintide, which was resolved by lowering the Cagrilintide dose to 0.17mg.